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. 2020 Sep 23;22:222. doi: 10.1186/s13075-020-02315-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — IL-22 and IL-25 expression in serum, synovial fluid, and synovial tissue from patients with rheumatoid arthritis (RA). a Concentrations of IL-25 were determined in the synovial fluid and serum of RA and OA, and healthy control subjects. b Correlations between the IL-22 and IL-25 concentrations were assessed in the synovial fluid and serum of patients with RA. c Expression of IL-25 was detected in the synovium of patients with RA and OA patients using immunohistochemical staining, with hematoxylin and eosin (H&E) counterstaining. Original magnification × 400. ***P < 0.001