TABLE 5.
Minor allele frequencies (MAF) for canine GST variants detected in boxer dogs with lymphoma (n = 63) compared to geriatric unaffected boxer dogs (n = 89)
| GSTT1 | MAF boxers with lymphoma a | MAF unaffected boxer dogs a |
|---|---|---|
| GSTT1 I2+168T>C | 0.014 | 0.013 |
| GSTT1 I4+70T>C | 0.026 | 0.000 |
|
GSTM1–399 to −400 insCGGAGCCGAGGGGGCG |
0.120 | 0.152 |
|
GSTM1–260 to −273 delCGGAGCCGAGGGGG |
0.677 | 0.763 |
|
GSTM1–231 to −244 delGGAGCCGAGGGGGC |
0.033 | 0.010 |
| GSTM1 c.422T>C | 0.022 | 0.007 |
| GSTP1–350C>A | 0.011 | 0.026 |
| GSTP1–228C>A | 0.000 | 0.038 |
| GSTP1–185 delT | 0.000 | 0.026 |
| GSTP1–68C>T | 0.021 | 0.013 |
|
GSTP1–66 to −16(GCC)n = 10‐22 Allele frequency listed for n = 17 unit repeats |
0.975 | 0.959 |
| GSTP1‐52 C>T | 0.011 | 0.013 |
| GSTP1‐48G>A | 0.023 | 0.006 |
| GSTP1‐46T>C | 0.011 | 0.019 |
| GSTP1‐43C>T | 0.043 | 0.019 |
| GSTP1‐37C>T | 0.011 | 0.006 |
| GSTP1‐27G>A | 0.064 | 0.026 |
| GSTP1‐21A>G | 0.032 | 0.013 |
| GSTP1 c.336T>C | 0.000 | 0.032 |
| GSTP1 c.548G>A | 0.000 | 0.008 |
Note: Allele frequencies were not significantly different between groups at any tested loci.
a
Allele frequencies could not be determined in all dogs at all loci.