TABLE 1.
Protease inhibitor concentrations in 31 dogs with acute pancreatitis and in 51 healthy control dogs
| Analyte | Controls a (n = 51) | Acute pancreatitis (n = 31) | P value | Adjusted P value b | |
|---|---|---|---|---|---|
| Antithrombin activitymin (%)c |
n (%) Median (range) |
25 (49) 160 (116‐200) |
25 (81) 119 (41‐193) |
<.001 | .004 |
| Antithrombin activity0 (%) c |
n (%) Median (range) |
25 (81) 149 (41‐193) |
.03 | .09 | |
| Antithrombin activity1 (%) c |
n (%) Median (range) |
25 (81) 134 (63‐194) |
.008 | .03 | |
| α2‐Antiplasmin activitymin (%) |
n (%) Median (range) |
28 (55) 100 (90‐186) |
25 (81) 99.0 (88‐106) |
.44 | |
| α2‐Antiplasmin activity0 (%) |
n (%) Median (range) |
25 (81) 102 (88‐108) |
.42 | ||
| α2‐Antiplasmin activity1 (%) |
n (%) Median (range) |
25 (81) 100 (91‐106) |
.64 | ||
| α1‐Proteinase inhibitormin (mg/L) d |
n (%) Median (range) |
28 (55) 1801 (1337‐2366) |
31 (100) 1701 (1390‐3251) |
.44 | |
| α1‐Proteinase inhibitormax (mg/L) d |
n (%) Median (range) |
31 (100) 1974 (1475‐3286) |
.05 | .11 | |
| α1‐Proteinase inhibitor0 (mg/L) |
n (%) Median (range) |
31 (100) 2037 (1390‐3286) |
.12 | ||
| α1‐Proteinase inhibitor1 (mg/L) |
n (%) Median (range) |
31 (100) 1788 (1400‐3251) |
.98 |
Abbreviation: n, number of cases.
Each analyte was measured once in the control group and twice in dogs with acute pancreatitis. Subscripts 0, 1, min and max refer to concentrations on day 0 (presentation), day 1 (1 day post‐presentation) and minimal or maximal concentrations during days 0 and 1, respectively.
Adjusted P value, significant raw P values were adjusted using the Benjamini‐Hochberg false discovery rate procedure.
Antithrombin activity reference interval is 87%<.
α1‐Proteinase inhibitor reference interval is 732‐1802 mg/L.