Table 2. Protocol violations.

Three main type of protocol violations occurred during the FU period; 1) patients with prolonged FU intervals (PV-1); 2) patients with USLs that were left untreated (PV-2); and 3) patients with inadequate FU after retreatment for recurrent ESCN (PV-3). Each PV could occur multiple times in a single patient.

	Number of patients (%)	Median frequency of occurrence per patient (range)
Prolonged FU intervals (PV-1)	24 (31%)	1 (1–3)
USLs that were left untreated (PV-2)	30 (38%)	1 (1–4)
Inadequate FU after new ESCN (PV-3)	4 (5%)	1 (1–3)
Any violation	46 (59%)	1 (1–4)