Table 5.

Comparison of five commonly used ADMET software programs.

Tools	Availability	Batch computation	Endpoints	Database	Druglikeness rules	Druglikeness model	Systematic evaluation	Medicinal chemistry friendliness properties	Physico- chemistry properties	Similarity	QSAR model	Algorithms	Training sets	Pattern recognition
SwissADME	Free	√	Number, 19 Contents: B, A, D, M	×	√	×	√	√	√	√	×	×	×	×
ADMETlab	Free	√	Number: 31 Contents: B, A, D, M, E, T	√ (288,967 entries; 5 similarity searching strategies)	√ (5 rules)	√	√	×	√	√	√	√	√	×
admetSAR 2.0	Free	×	Number: 47 Contents: B, A, D, M, E, T	√ (210,000 entries)	×	×	√	×	√	√	√	√	√	×
Lazar	Free	×	Number: 11 Contents: T: Acute toxicity; BBB; Carcinogenicity, LOAEL, Maximum Recommended Daily Dose, Mutagenicity	×	×	×	×	×	×	√	√	√	√	√
ToxTree	Free	×	Number: 6 Contents: M, T	×	×	×	×	×	×	√	×	×	×	√

B, basic physicochemical property; A, absorption; D, distribution; M, metabolism; E, excretion; T, toxicity.