Table 7.

Comparison of commonly used PBPK software programs for two categories.

User customized software	Latest version	Modeling language	Auxiliary tool	Operation method	Model
WinNonlin	WinNonlin v6.4	R	Phoenix® NLME™	Built-in options or a combination of graphics and text commands	Non-compartmental analysis (NCA)
NONMEM	NONMEM v7.3	FORTRAN	Wings for NONMEM, priana	Fully based on text	Two-compartment or three-compartment model
User-friendly software	Company	Species	Routes of administration	Features	Application
GastroPlus	Simulations Plus Inc.	Human, rat, dog, mouse, monkey, user defined	i.v., p.o., ocular, pulmonary, lingual, sublingual, buccal	ACAT model PEAR function	Ten modules for PBPK modeling, built-in multi-person physiological treatment model, IVIVC; single simulation, batch simulation, parameter sensitivity analysis (PSA), population simulation
SimCYP	Certara USA Inc.	Human, rat, mouse, dog	i.v., p.o., pulmonary, skin	ADAM model, Extensive data base with physiological information	PBPK modeling function, IVIVE; DDI simulation and population differential prediction; time course of simulated metabolites
PK-Sim	Bayer Technology Services	Human, rat, mouse, dog, monkey, minipig	i.v., p.o., subcutaneous, dermal, user defined	WB-PBPK model, various PBPK calculation methods	High-flexibility-all model parameters accessible for specific investigations; Simulating physiological variability in reactions