Figure 1.

M10 ameliorated dextran sodium sulfate (DSS)-induced ulcerative colitis in mice. (A) Mice body changes during colitis induced by four DSS cycles exposure. (B) Mice body changes in various treatments during first 7 days regular water in fourth DSS cycle. As compared to normalized normal mice (blue color), model mice continued body weight loss for 3–4 days, and then slowly recovered, while body weight in the M10-treated mice did not significantly loss (50 mg/kg-treated mice) or recovered earlier after exposure to distilled water (25- and 100 mg/kg-treated mice). (C) Administration of M10 significantly reduced DAI scores during colitis in fourth DSS cycle. Normal mice did not demonstrate any symptoms of illnesses. Model mice were scored the highest DAI. (D) Length of colorectums in different mice groups. (a) Normal mice; (b) Model mice; (c) Myricetin-treated mice; (d-f) M10-treated mice by 25, 50, and 100 mg/kg, respectively; (g) Mesalazine-treated mice; (h) Statistical analysis of length of colorectums in different mice groups. Each dot represents six mice (n = 6). *p < 0.05, **p < 0.01 vs. model mice as well as Myricetin- or Mesalazine-treated mice.