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M10 prevented necroptosis during ulcerative colitis. (A) M10 prevented DSS-induced ultrastructural changes of colonic epithelial cells. (a) Normal mice; (b) Model mice; (c) Myricetin-treated mice; (d) M10-treated mice by 50 mg/kg; (e) Mesalazine-treated mice. (B) M10 reduced the expression of necroptosis-related proteins, TNF-α, caspase-8, RIPK1, p-RIPK1, RIPK3, p-RIPK3, MLKL, p-MLKL. N = 6. *p < 0.05, **p < 0.01 vs. model mice.
