Figure 9.

HCN3 Mediation of PGE₂-Evoked Excitation and Burst Discharges in OT Neurons. (A) Effects of HCN3 inhibitor, DK-AH269, on PGE₂ effects: exemplary firing episodes (a) and the summary (c–e). Note that, n = 10 before DK-AH269, n = 10 in DK-AH269, and n = 6 in DK-AH269 + PGE₂. (B) Effect of DK-AH269 and PGE₂ on AHP of OT neurons (Ba) and the summary in bar graphs (b–d). Note that, n = 10 before DK-AH269, n = 10 in DK-AH269, and n = 5 in DK-AH269 + PGE₂. *p < .05 versus before DK-AH269 by ANOVA. HCN3 = hyperpolarization-activated cyclic nucleotide-gated channel 3; OT = oxytocin;

PGE₂ = prostaglandin E₂.