Table 5.

Comparison between different HIS humanized mouse models.

	Hu-PBL-SCID	SRC-Hu	Thy/HSC (BLT)
Accessibility of human sample	Good	Moderate	Difficult (potential ethic problem)
Technique for model construction	Easy	Moderate	Relative difficult (required anesthesia and transplant technique)
Human immune cell survival/development	Majority of activated human T cells; Transient human B cells, myeloid cells and NK cells;	Multi-lineage human immune cell reconstitution; Poor human thymopoiesis; Lack of HLA mediate thymic selection for human T cells.	Multi-lineage human immune cell reconstitution; Robust human thymopoiesis; Human TCR repertoire influenced by mouse antigen.
Human immune function	T cell responses; Lack of interaction between human T cells, B cells, and myeloid cells.	Poor HLA restricted T cell responses; Poor T cell-dependent humoral responses.	Good HLA restricted T cell responses; Good T cell-dependent humoral response.
Time window	Short	Long	Long