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. 2020 Sep 11;10:1500. doi: 10.3389/fonc.2020.01500

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Copyright © 2020 Raiter, Lipovetsky, Hyman, Mugami, Ben-Zur and Yerushalmi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemotherapy induced nuclear translocation of CREB3L1 in MDAMB231 cells. Immunofluorescence analysis of GRP78 and CREB3L1 expression 24 h after cell treatment with doxorubicin and paclitaxel: (A) MCF7 cells, (B) BT474 cells, (C) MDAMB468 cells, (D) MDAMB231 cells. Note GRP78 staining (red), CREB3L1 staining (green), and merged staining (yellow) by cell type (63 × magnification, scale bar = 10 μm). (E) Fluorescence intensity (FI) of CREB3L1 and GRP78 expression. (F) Dot Blot FACS analysis of the cytoplasmic and nuclear expression of CREB3L1 in the different breast cancer cell lines.