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. 2020 Sep 11;10:1500. doi: 10.3389/fonc.2020.01500

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Copyright © 2020 Raiter, Lipovetsky, Hyman, Mugami, Ben-Zur and Yerushalmi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemotherapy fails to prevent metastasis in mice injected with MDAMB231 CREB3L1-KO cells. (A) Representative histological lung sections stained with H&E showing metastasis in mice injected IV with MDAMB231 control cells, compared to the group inoculated with CREB3L1-KO cells and after chemotherapy. (B) Number and size (in mm) of lung foci were assessed manually in three mice in each group (C) Lungs extracted from mice. (D) Histological sections showing metastasis in lungs of mice inoculated with MDAMB231 or CREB3L1-KO cells. Immune staining for CREB3L1 (green) and GRP78 (red). Nuclei of cells stained with DAPI. Immunofluorescence images obtained under a confocal microscope and analyzed with Zen2Pro Zen. Inc software (×40, scale bar = 200 μm).