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. 2020 Sep 11;11:572475. doi: 10.3389/fimmu.2020.572475

FIGURE 2.

FIGURE 2

Modulation of CD95 expression on B cell subsets during IL-6R and TNF-α inhibition therapy. For CD19+CD95+ expressing cells from all B cell subsets, including total B cells, pre-switch memory, and post-switch memory B cells, are significantly reduced during IL-6R inhibition (A) and TNF-α inhibition (B) therapy. CD19+Ki-67+ expressing cells from all B cell subsets are significantly reduced during IL-6R inhibition (C) and TNF-α inhibition (D) therapy. Values were consistently compared with baseline levels by using the Student unpaired t-test (***p < 0.0001, **p < 0.001, and *p < 0.01). BL = baseline, W12 = week 12, and W24 = week 24.