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. 2020 Sep 11;11:572475. doi: 10.3389/fimmu.2020.572475

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Copyright © 2020 Mahmood, Schmalzing, Dörner, Tony and Muhammad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between activated B cells and disease activity. A significant correlation can be observed between activated B cells, identified by their CD95+ or Ki-67+ expression, and DAS28 as a measure of RA disease activity (A). Among B cell subsets, post-switch exhibits a positive correlation, pre-switch a negative correlation, while double-negative (DN) B cells fail to demonstrate any correlation with DAS28 (B). The relationship between variables was evaluated using the Pearson linear correlation test. A two-sided p-value of <0.05 was considered statistically significant.