FIGURE 5.

Expression of CXCR3 and CXCR4 in B cell subsets during IL-6R and TNF inhibition therapy. CXCR3 expression on B cell subsets increases in some subsets during IL-6R inhibition (A) and decreases during TNF-α inhibition (B) therapy. CXCR4 expression on B cell subsets reduces in certain subsets during IL-6R inhibition (C) and TNF-α inhibition (D) therapy. Values were consistently compared with baseline levels using the Student unpaired t-test (***p < 0.0001, **p < 0.001, and *p < 0.01). BL = baseline, W12 = week 12, and W24 = week 24.