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. 2020 Sep 11;10:1534. doi: 10.3389/fonc.2020.01534

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Copyright © 2020 Islam, Gopalan, Law, Lam and Pillai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the methodological flow used for clinical samples analysis in the present study. Tissue samples with poor histology and loss of follow-up were excluded in the present study. Among the samples, 45% showed EPAS1 DNA amplification, whereas 42.5% showed EPAS1 DNA deletion. The rest of the samples (12.5%) showed no changes in EPAS1 DNA. In addition, 53.8% of samples showed high EPAS1 mRNA expression, and 16.2% of samples showed low EPAS1 mRNA expression, whereas 20% of samples did not show any changes in EPAS1 mRNA expression. Furthermore, 12.5% of samples showed EPAS1 mutations, and 87.5% of samples were mutation negative in the present study.