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. 2020 Sep 11;10:1534. doi: 10.3389/fonc.2020.01534

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Copyright © 2020 Islam, Gopalan, Law, Lam and Pillai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship of EPAS1 molecular dysregulation in ESCC. (A) EPAS1-mutated samples showed significant amplification of DNA number in comparison to that of nonmutated samples (p < 0.05). (B) Similarly, EPAS1-mutated samples exhibited significant higher expression (mRNA) when compared to that of nonmutated tissue samples (p < 0.05). (C) Association of EPAS1 DNA number changes and mRNA expression. RT-qPCR analysis revealed that EPAS1 DNA number amplification significantly correlated with mRNA overexpression (p < 0.01). A 84% patients having EPAS1 DNA amplification showed mRNA overexpression whereas 59% patients with EPAS1 DNA deletion showed mRNA overexpression. (D) Distribution of EPAS1 mRNA expression vs. EPAS1 DNA number in patients with ESCC. Patients with DNA number greater 2 showed higher mRNA expression and DNA number <2 showed lower EPAS1 mRNA expression.