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. 2020 Sep 11;10:1534. doi: 10.3389/fonc.2020.01534

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Copyright © 2020 Islam, Gopalan, Law, Lam and Pillai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EPAS1 suppression inhibited ESCC cells proliferation and colony formation. in vitro suppression of EPAS1 using siRNA in KYSE70 (A) and KYSE150 (B) cells caused significant reduction in proliferation at different time points when compared with untreated and scramble control cell groups. In addition, silencing of EPAS1 induced significant reduction of colony formation capacity KYSE70 (C) and KYSE150 (D) cells in comparison to that of control groups. (E) Expression of EPAS1 protein in KYSE70 and KYSE150 cells followed by siRNA treatment. (F) Relative expression of EPAS1 in KYSE70 and KYSE150 cells followed. EPAS1 siRNA1 ans siRNA2 significantly inhibited the expression of EPAS1 in KYSE70 and KYSE150 cells. Results are shown as mean ± SD and significance level was taken at p < 0.05. *p < 0.05, **p < 0.01, and ***p < 0.001.