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. 2020 Sep 11;10:1534. doi: 10.3389/fonc.2020.01534

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Copyright © 2020 Islam, Gopalan, Law, Lam and Pillai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing of EPAS1 causes reduction of wound healing, invasion and migration of ESCC cells. Silencing of EPAS1 causes inhibition of wound healing of ESCC cells as suppression of EPAS1 induced reduction of migration capacity of KYSE70 (A) and KYSE150 (B) cells, thereby healing the wound more slowly in comparison to that of untreated wild type and scramble control cells. Similarly, a significantly reduced population of KYSE70 (C) and KYSE150 (D) cells exhibited invasion and migration followed by suppression of EPAS1 when compared to that of untreated or scramble control cells. Results are shown as mean ± SD, and significance level was taken at p < 0.05. *p < 0.05 and **p < 0.01.