Fig. 10.

Selected upstream transcription factors unique to lung or right ventricle (RV). Predicted activated (A, C) or inhibited (B, D) upstream transcription factors in lungs (A, B) and RVs (C, D) from rats exposed to in utero and postnatal hypoxia vs. normoxic controls. In the lung, T-box transcription factor 2 (TBX2) and mesenchyme homeobox 2 (MEOX2) were predicted activated (A), whereas signal transducer and activator of transcription 1 (STAT1) and proto-oncogene, NF-κB subunit (RELA) were predicted inhibited (B). In the RV, predicted activated upstream transcription factors identified included mothers against decapentaplegic homolog 7 (SMAD7) and clock circadian regulator (CLOCK; C), whereas hypoxia-inducible factor 1α (HIF1A) and STAT1 were predicted inhibited (D). Corrected P values and z-scores for these transcription factors are shown in boxes below each diagram. Hubs identify transcription factors, spokes identify their targets (see legend for further details).