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. 2020 Jun 17;319(3):L422–L434. doi: 10.1152/ajplung.00040.2020

Table 1.

Nomenclature for the RELM/FIZZ/XCP family of proteins

RELM Family Members Cellular Source (RELM-Producing Cells)
Murine/rodent (m) classification
    FIZZ1 = RELMα = HIMF = XCP2 Macrophages (107), dendritic cells (20), and other immune cells (bone marrow cells and splenocytes) (30); bronchial epithelial cells, and type II pneumocytes
    FIZZ2 = RELMβ = XCP3 Goblet cells (7), lung epithelial cells (78)
    FIZZ3 = Resistin = ADSF = XCP4 Adipocytes (59)
    FIZZ4 = RELMγ = XCP1 Immune cells (bone marrow and white blood cells, splenocytes and thymocytes) (36, 115), adipocytes, and pneumonocytes (36)
Human (h) classification
    Resistin = RELMα = FIZZ1 = XCP1 Macrophages, monocytes, and neutrophils (50)
    RELMβ = FIZZ2 = XCP2 SMCs, macrophages, and T cells (6), ECs and fibroblasts (33)

ADSF, adipose tissue-specific secretory factor; ECs, endothelial cells; FIZZ, found in inflammatory zone; HIMF, hypoxia-induced mitogenic factor; RELM, resistin-like molecule; SMCs, smooth muscle cells; XCP, 10-cysteine protein.