Table 1.
RELM Family Members | Cellular Source (RELM-Producing Cells) |
---|---|
Murine/rodent (m) classification | |
FIZZ1 = RELMα = HIMF = XCP2 | Macrophages (107), dendritic cells (20), and other immune cells (bone marrow cells and splenocytes) (30); bronchial epithelial cells, and type II pneumocytes |
FIZZ2 = RELMβ = XCP3 | Goblet cells (7), lung epithelial cells (78) |
FIZZ3 = Resistin = ADSF = XCP4 | Adipocytes (59) |
FIZZ4 = RELMγ = XCP1 | Immune cells (bone marrow and white blood cells, splenocytes and thymocytes) (36, 115), adipocytes, and pneumonocytes (36) |
Human (h) classification | |
Resistin = RELMα = FIZZ1 = XCP1 | Macrophages, monocytes, and neutrophils (50) |
RELMβ = FIZZ2 = XCP2 | SMCs, macrophages, and T cells (6), ECs and fibroblasts (33) |
ADSF, adipose tissue-specific secretory factor; ECs, endothelial cells; FIZZ, found in inflammatory zone; HIMF, hypoxia-induced mitogenic factor; RELM, resistin-like molecule; SMCs, smooth muscle cells; XCP, 10-cysteine protein.