Table 3.
Metabolite concentrations in the region of interest in AB-ADs, NA-ADs, and health controls.
| AB-ADs(n=40) | NA-ADs(n=40) | HCs(n=40) | pa | p1 | p2 | p3 | |
|---|---|---|---|---|---|---|---|
| NAA/CR left frontal cortex |
2.27 ± 0.54 | 3.26 ± 0.78 | 3.87 ± 0.77 | 0.038 | 0.027 | 0.046 | 0.04 |
| right frontal cortex | 3.18 ± 0.64 | 3.42 ± 0.56 | 3.74 ± 0.46 | 0.12 | 0.047 | 0.13 | 0.11 |
| left amygdala | 1.92 ± 0.72 | 1.96 ± 0.61 | 2.48 ± 0.74 | 0.044 | 0.042 | 0.043 | 0.12 |
| right amygdala | 1.87 ± 0.55 | 1.96 ± 0.51 | 2.03 ± 0.65 | 0.22 | 0.18 | 0.21 | 0.09 |
| Cho/Cr left frontal cortex |
1.24 ± 0.33 | 1.32 ± 0.45 | 1.78 ± 0.32 | 0.045 | 0.03 | 0.032 | 0.10 |
| right frontal cortex | 1.15 ± 0.34 | 1.08 ± 0.56 | 1.56 ± 0.65 | 0.03 | 0.043 | 0.037 | 0.08 |
| left amygdala | 3.25 ± 1.24 | 4.56 ± 1.03 | 4.58 ± 1.14 | 0.04 | 0.027 | 0.035 | 0.03 |
| right amygdala | 3.65 ± 0.55 | 3.97 ± 0.51 | 5.82 ± 0.45 | 0.044 | 0.038 | 0.043 | 0.034 |
| Glu/Cr left frontal cortex |
5.21 ± 1.21 | 5.56 ± 1.32 | 5.34 ± 1.03 | 0.14 | 0.09 | 0.1 | 0.11 |
| right frontal cortex | 4.85 ± 1.66 | 4.97 ± 1.56 | 5.01 ± 1.34 | 0.11 | 0.13 | 0.15 | 0.14 |
| left amygdala | 8.75 ± 3.65 | 5.06 ± 2.78 | 4.98 ± 2.65 | 0.03 | 0.01 | 0.07 | 0.02 |
| right amygdala | 7.82 ± 3.25 | 5.36 ± 2.02 | 4.54 ± 2.33 | 0.043 | 0.03 | 0.11 | 0.04 |
AB-ADs, aggressive behavior-alcohol dependent patients; HCs, healthy controls; NA-Ads, non-aggression-alcohol dependent patients; NAA, n-acetyl-aspartate; Cho, choline; Glu, glutamate; Cr, creatine.
pa ANOVA,
p1aggressive behavior-alcohol dependent patients vs healthy controls,
p2 non-aggression-alcohol dependent patients vs healthy controls,
p3 aggressive behavior-alcohol dependent patients vs non-aggression-alcohol dependent patients vs healthy controls.