TABLE 2.

Gradation of CIP.

Grades	Description
G1	No symptom
	Limited to a single lobe or <25% lung parenchyma
G2	New symptoms or worsening symptoms, including shortness of breath, cough, chest pain, fever, and anoxia
	Involves multiple lung lobes and reaches 25–50% of lung parenchyma, affecting daily life, requiring drug intervention
G3	Serious new complications
	Involves all lung lobes or >50% of lung parenchyma, limited personal self-care ability, requiring oxygen inhalation and hospitalization
G4	Life-threatening dyspnea, acute respiratory distress syndrome (ARDS) requiring urgent intervention such as intubation

CIP, checkpoint inhibitor pneumonitis.