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. 2020 Sep 11;8:567028. doi: 10.3389/fcell.2020.567028

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Copyright © 2020 Min, Long, Zhao, Zhen, Li, Li, Fan, Yu, Zhao and Qiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lysine acetylation of proteins regulates metabolic pathways in PCOS granulosa cells. (A) The diagram of metabolism pathways with differentially acetylated enzymes highlighted. Red color represented the enzyme with hyperacetylation in the PCOS group; green color represented the enzyme with hypoacetylation in PCOS group; and blue color represented the important metabolites and metabolic pathways. (B–E) Verification of lysine acetylation changes of key enzymes. Immunoprecipitated proteins and acetylation status of target proteins were detected by Western blot. GAPDH (glyceraldehyde-3-phosphate dehydrogenase), PGK1 (phosphoglycerate kinase 1), PGAM1 (phosphoglycerate mutase 1), ACAT1 (acetyl-CoA acetyltransferase 1).