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. 2020 Sep 25;23(10):101611. doi: 10.1016/j.isci.2020.101611

Figure 8.

Figure 8

PPARγ-RXRA-NR3C1 Cistrome Repression in COVID-19 Lungs and SUMO1-SARS Interaction

(A) Phastconservation plot of PPARγ CHIP-seq data from the THP-1 cell line (HG38 human genome) mapped on a database of mammalian promoters; (B) Signal-promoter plot of PPARγ CHIP-seq data from THP-1 integrated with the repression signature found in COVID-19 lung transcriptomes (size of the circle is proportional to the negative logRatio found in the COVID-19 lung transcriptome, mapping +/− 100 kb around transcription starting sites [TSS]); (C) Promoter heatmap for PPARγ-RXRA-NR3C1 cistrome and POLR2A from CHIP-seq data from THP-1 adapted to the repression signature found in the COVID-19 lung transcriptome (mapping +/− 5 kb around TSS); (D) PPARγ CHIP-seq signal found in the promoter of RGS12, mapped with POLR2A and Histone H3 K27 acetylation in THP-1 cells; (E) UMAP representation of single-cell transcriptome (bronchoalveolar lavage fluid) expression of RGS12 in HDs or patients with mild or severe COVID-19; (F) Human-SARS protein-protein interactome network, with integration of the PPARγ complex affected in COVID-19 lung infection (edges represent connections found in VirusHostNet database).