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. 2020 Sep 24;10:15581. doi: 10.1038/s41598-020-72705-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Undernutrition leads to growth failure and is often associated to environmental enteric dysfunction (EED). We aimed to develop a preclinical model of undernourished model with environmental enteropathy features such high intestinal inflammation and intestinal permeability. To induce undernutrition with EED, post-weaning C57BL/6 mice were fed with malnourished diet alone or combined with a gastrointestinal insult trigger. Growth was assessed by body weight and tail length. Intestinal permeability and inflammation were used as enteropathic markers. CR and LP for 3 weeks induced stunting and wasting but had no intestinal impact. We therefore decided to combine LP diet to a gastrointestinal insult trigger by liposaccharides (LPS) or indomethacin. LPS did not significantly impact small intestine while indomethacin increased fecal calprotectin production. To accentuate the effects, we investigated the effects of repeated gavages of indomethacin in addition to LP diet and mice exhibited stunting and wasting with intestinal hyperpermeability and gut inflammation.