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. 2020 Sep 24;10:15701. doi: 10.1038/s41598-020-72924-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ketamine/xylazine was cardiodepressive in both lean and obese ZSF1 rats. M-mode images of 20-weeks-old isoflurane- and ketamine/xylazine-anaesthetised lean and obese ZSF1 rats (n = 7 per group) (a). Heart rate (b), cardiac output (c), and stroke volume (d) in 20-week-old isoflurane- or ketamine/xylazine-anaesthetised lean and obese ZSF1 rats. Values are presented as mean ± SD. **P < 0.01 and *** < 0.001. AW, anterior wall; EDD, end-diastolic diameter; ESD, end-systolic diameter; HB, heartbeat; Ket/Xyl, ketamine/xylazine; PW, posterior wall.