Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 25;5:196. doi: 10.1038/s41392-020-00248-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — J4 synergizes with Apa in the suppression of osteosarcoma tumor growth. a Analysis of the synergism between J4 and Apa. The corresponding combination index (CI) vs. fraction affected (Fa) plots of J4 and Apa under different drug concentration conditions in osteosarcoma cell lines. b IC₅₀ values of SJSA-1 and 143B (non-stem-like) and MSCs treated with J4+Apa for 48 h. c The cell viability inhibition curve of J4 or/and Apa in SJSA-1 or 143B cells (non-stem-like). d The non-stem-like cells were treated with different formulations for 24 h in Matrigel matrix-coated invasion chambers. Cells that reached the bottom of the membranes were photographed (scale bar = 200 μm). e, f SJSA-1 cells (non-stem-like) were subcutaneously injected into the right hind leg to establish osteosarcoma xenograft model (e). The tumor-bearing nude mice were administered intravenously (i.v.) with different therapeutic formulations. The representative images at day 30 are presented as f tumor growth curves of different formulations in SJSA-1 (non-stem-like) tumor-bearing mice. P values were calculated using Student’s t-test (***P < 0.001, **P < 0.01, or *P < 0.05)