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. 2020 Sep 25;5:196. doi: 10.1038/s41392-020-00248-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Characterization of NPs and NPJ4+Apa. a TEM of GSH-sensitive NPs (upper) and NP loading with J4 and Apa (NP_J4+Apa, lower). The scale length of the TEM image is 200 nm. b DLS micrographs of NPs and NP_J4+Apa. c Zeta potential of NP_J4+Apa dispersed in DI water. d Particle size of NP_J4+Apa in DI water, PBS, or 10% serum in DMEM solutions measured using DLS. e In vitro Apa (left) and J4 (right) release from NP_J4+Apa in PBS at different concentrations of GSH. f In vitro Apa (left) and J4 (right) release from NP_J4+Apa in PBS at different pH. g Penetration of coumarin-6-loaded NPs (NP_C6) in the SJSA-1 and 143B-derived OS spheroids. The spheroids were incubated with free C6 or NP_C6 for 30 min (green, C6). Flow cytometric quantification of C6 fluorescence intensity after treatment. The scale length of each image is 25 μm. h Representative in vivo fluorescence images of mice taken at three different time points (0, 12, and 24 h) after intravenous injection of saline (Ctrl), free DiR, or NP_DiR. i The ex vivo fluorescence image of isolated tumors at 24 h post-injection