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. 2020 Sep 25;5:196. doi: 10.1038/s41392-020-00248-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Scheme 1 — Schematic illustration of GSH-scavenging nanoparticles for synergistic suppression of chemotherapy-resistant osteosarcoma. Single-cell transcriptomics indicate VEGFR2-JMJD3-abundant cells in the stem-like/progenitor populations in osteosarcoma. NP_J4+Apa could effectively load and release the Apa (VEGFR2 inhibitor) and J4 (JMJD3 inhibitor), increase endoplasmic reticulum stress-induced apoptosis, and exhibit significant potency against osteosarcoma stem-like/progenitor cell-derived tumors