FIGURE 1.

Study design. Female C57BL/6N mice (dams) were fed either a control (control dams) or western diet(obese dams) from weaning (age 3 weeks). At 12‐weeks post weaning, dams were put into cages with (exercise) or without (sedentary) a running wheel. The dams were bred with male mice fed the control diet 1 week later. Dams had access to the running wheel throughout breeding, pregnancy and lactation. Offspring were weaned at age 3 weeks onto the control diet or western diet and fed for 14 weeks