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. 2020 Sep 25;8(18):e14582. doi: 10.14814/phy2.14582

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© 2020 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Exercise in dams with diet‐induced obesity had no effect on thoracic aorta endothelial‐dependent vasodilatation in adult male offspring fed the control diet. (a) Control diet‐fed offspring body weight at weaning and (b) at age 14 weeks. At age 14–15 weeks, aortic rings were harvested from offspring and vasodilatation were assessed in response to (c,d) acetylcholine (Ach) and (e,f) sodium nitroprusside (SNP) for endothelial‐dependent and endothelial‐independent vasodilatation, respectively. (g) Vasoconstriction assessed in response to phenylephrine . For bar graphs, values for each individual mouse presented; bar graphs represent mean ± SD (n = 7–11/group). Symbols represent mean ± SD (n = 5–6/group) at each drug concentration. Data were analyzed by repeated measures ANOVA and symbols represent mean ± SD