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. 2020 Aug 27;14:274. doi: 10.3389/fncel.2020.00274

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Copyright © 2020 Comer, Carrier, Tremblay and Cruz-Martín.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overlap between immune-signaling genes that are associated with pollution and SCZ. Of the immune genes that are associated with SCZ, many are also found to be altered either in humans or animals exposed to pollutants, offering a genetic point of convergence between changes in pollution-mediated inflammatory signaling and SCZ. Inflammatory gene expression, including TLR2, TNF-α, MHC, CRP, TLR4, IRF3, complement pathway, IL-6, IFN-y, CD14, IL-10, TGF-β are altered in SCZ, while TNF-α, TLR4, IL-6, CD14 and IL-1 are altered in SCZ and after exposure to air pollution. These genes are specifically enriched in microglia.