Table 2.
Effects of bisphenols on Sertoli cells.
| Chemical name | Dosage | Species | Effects | References |
|---|---|---|---|---|
| BPA | 50 mg/kg (Rats) | Sprague–Dawley rats and Wistar rats (20 day old); | Disruption of the blood-testis barrier integrity | (19) |
| BPA | 200 μM (Sertoli cell) | Sertoli cells (20-day-old Sprague-Dawley rats) | Perturbation of Sertoli cell tight junction permeability barrier | (19) |
| Activation of ERK1/2 in the cell | ||||
| Downregulation of basal ectoplasmic specialization and gap junction at the blood-testis barrier | ||||
| BPA | 150–200 μM | 18-day-old Wistar rats Sertoli cell | Decreased cell viability | (96) |
| Induction of membrane blebs, cell rounding, cytoskeletal collapse, chromatin condensation, and DNA fragmentation | ||||
| Expression of caspase-3 | ||||
| Disorganization of the actin cytoskeleton | ||||
| Decreased hormone (transferrin) secretion | ||||
| BPA | 200 μM | Mouse Sertoli TTE3 cells | Induction of cellular damage and apoptosis | (97) |
| Induction of endoplasmic reticulum stress | ||||
| Endoplasmic reticulum Ca2+ homeostasis blockage | ||||
| BPA | 20 and 200 μg/kg | ICR mice (3 months old) | Impairment of ectoplasmic specialization between the Sertoli cell and spermatids | (98) |
| Wistar rat (4 months) | Incomplete, redundant ectopic specialization | |||
| BPA | 200 μM | Rat and SerW3 Sertoli cell line | Perturbation of the Sertoli cell tight junction permeability barrier function | (99) |
| Downregulation of blood-testis barrier proteins | ||||
| Redistribution of blood-testis barrier-associated proteins | ||||
| Alteration of the distribution of integral membrane proteins and their peripheral adaptors | ||||
| BPA | 45 μM | SerW3 Sertoli cells | Alterations of Sertoli cell functions | (101) |
| Metabolic, endocrine and/or paracrine dysfunctions | ||||
| BPA | 50 mg/kg | ICR mice (6 weeks) | Downregulation of Sertoli cell-related genes (Msi1h, Ncoa1, Nid1, Hspb2, and Gata6) | (102) |
| BPA | 2.4 μg/kg/day | Neonatal Holtzman rat | Impairment of fertility | (105) |
| Perturbations tight junctions and decreased expression of junctional proteins | ||||
| BPA | 40 and 200 μM | Human Sertoli cell (12, 23, and 36-year old) | Truncation and depolymerization of actin | (106) |
| Microfilaments | ||||
| Disorganization of F-actin | ||||
| Changes in the localization and distribution of F-actin regulatory proteins in Sertoli cell epithelia | ||||
| Retraction of actin microfilaments | ||||
| BPA | 4, 40, and 400 mg/kg | Sprague–Dawley rat | Downregulation of Sertoli cell genes | (57) |