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. 2020 Sep 24;10:15676. doi: 10.1038/s41598-020-72485-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cell proliferation was decreased in hNPCs exposed to high glucose. (a) Representative images of hNPCs expressing neural stem cell markers i.e., Nestin (i) SOX2 (ii), and Musashi1 (iii). Nuclei are stained with DAPI (blue). (b) There was significant decrease in cell proliferation index in hNPCs exposed to high glucose as depicted by MTS assay in n = 4, ***p < 0.001. (c) Western blot analysis revealed decrease expression of Nestin and Musashi1 in hNPCs exposed to HG for 96 h. (d) Quantitative analysis shows significant decrease in Nestin (Observed band size 300 kDa, Cat. no. ab18102, Abcam) and Musashi1 (39 kDa) protein expression in hNPCs exposed to HG for 96 h. Data is represented as Mean ± SE, n = 4, *p < 0.05, **p < 0.01. Uncropped blot images are shown in Supplementary Fig. S2.