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. 2020 Sep 24;10:15676. doi: 10.1038/s41598-020-72485-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Hippo genes were significantly decreased in hNPCs under HG condition. (a) Western blot analysis revealed decrease in expression of YAP in hNPCs under HG condition. (b) Quantitative analysis shows significant decrease in YAP (70 kDa) protein expression in hNPCs exposed to HG condition. Data is represented as Mean ± SE, n = 3, *p < 0.05. (c) Immunocytochemical analysis confirmed the decrease in YAP (Red) expression in hNPCs exposed to HG. Musashi1 is in green while DAPI is in blue, scale bar = 30 μm. (d) Western blot analysis revealed decrease expression of TAZ in hNPCs exposed to HG condition. (e) Quantitative analysis shows significant decrease in TAZ (55 kDa) protein expression in hNPCs exposed to HG condition. Data is represented as Mean ± SE, n = 3, ***p < 0.001. (f) Immunocytochemical analysis confirmed the decrease in TAZ (Green) expression in hNPCs exposed to HG. Nestin is in red while DAPI is in blue, n = 3, scale bar = 10 μm. (g) Western blot analysis revealed significant decrease in TAZ expression in hNPCs following SLIT1 knockdown. (h) Quantitative analysis shows significant decrease in TAZ expression in hNPCs following SLIT1 knockdown. Data is represented as Mean ± SE, n = 3, **p < 0.01. Uncropped blot images are shown in Supplementary Fig. S2.