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. 2020 Sep 2;1(6):100091. doi: 10.1016/j.patter.2020.100091

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Tissue-Wise Enrichment Statistics for SCZ- and MAPSD-Identified Genes at Gene Expression Level

(A) –log10(p value) of SCZ and MAPSD risk genes with the highest signal intensity in brain tissues in GTEx consortium gene expression data.

(B) The number of differentially expressed SCZ and MAPSD risk genes in the cerebral cortex (CBC), dorsolateral frontal cortex (DFC), and hippocampus (HIP) between prenatal and postnatal developmental stages using BrainSpan data.

(C) Number of MAPSD risk genes to be the targets of FDA-approved drugs being enriched in specific cell types in certain brain regions.

(D) Percentage of SCZ-associated genes to be direct neighbors of the MAPSD-identified genes where each color represents MAPSD genes with a certain number of immediate connecting nodes in the PPI network.