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. 2020 May 12;75(10):1863–1873. doi: 10.1093/gerona/glaa116

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Figure 2. — Association between Apolipoprotein E ε4 (APOE*4) and cognitive decline in men. (A) Mean annual rates of change in Mini-Mental State Examination (MMSE) performance and standard errors for men aged 62 years (younger) and 80 years (older) at baseline in each of the APOE*4 groups. (B) Mean annual rates of change in memory performance and standard errors for men aged 62 years (younger) and 80 years (older) at baseline in each of the APOE*4 groups. (C) Fitted trajectories plotting changes in MMSE performance over time in 62-year-old (younger) and 80-year-old (older) males in each of the APOE*4 groups. (D) Fitted trajectories plotting changes in memory performance over time in 62-year-old (younger) and 80-year-old (older) males in each of the APOE* groups. (E) Fitted trajectories plotting changes in MMSE scores in 80-year-old (older) male and female heterozygotes and homozygotes.