Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 30;75(10):1811–1819. doi: 10.1093/gerona/glz225

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

PMC Copyright notice

Figure 3. — Forest plots for selected associations with strong effect of the antagonistic genetic heterogeneity. Black and gray (blue on-line) show associations from the unconditional and conditional models, respectively, for minor alleles of: (A) rs780094 (GCKR locus) with HDL-C; conditioning is on TG, (B) rs17145738 (MLXIPL locus) with TC; conditioning is on LDL-C, (C) rs289715 (CETP locus) with LDL-C; conditioning is on TC, and (D) rs780094 (GCKR locus) with LDL-C; conditioning is on TC. Figures (A)–(C) illustrate three modes of strengthening the associations by dissecting the antagonistic genetic heterogeneity, ie, (A) increasing magnitude of the effect size, (B) decreasing the standard error, and (C) both. Figure (D) illustrates changes in the effect directions in opposite fashion in conditional and unconditional models. Bars show standard errors (SE). Cohorts: Atherosclerosis Risk in Communities Study (ARIC); Coronary Artery Risk Development in Young Adults (CARDIA); Cardiovascular Health Study (CHS); Framingham Heart Study (FHS) original cohort (FHS_C1); FHS offspring (FHS_C2); FHS 3rd generation cohort (FHS_C3), Health and Retirement Study (HRS); the Multi-Ethnic Study of Atherosclerosis (MESA), and Women’s Health Initiative (WHI). HDL-C = High-density lipoprotein cholesterol; LDL-C = Low-density lipoprotein cholesterol; TC = Total cholesterol; TG = Triglycerides.