Fig 4. The mean AUC values extracted from the included studies against PZQ dose of (R)-PZQ [I, II], (S)-PZQ [III, IV], and the major metabolite (R)-trans-4-OH-PZQ [V, VI] at 20, 40, and 60 mg/kg.

The data are extracted from Kovac and colleagues [56], which investigated S. mansoni and S. haematobium infected PSAC (●) and SAC (○) treated with PZQ. The AUC values were then plotted against the dose of PZQ administered for further analysis. P < 0.05 was considered statistically significant; a: significant difference between SAC and PSAC for the same dose and analyte, b: significant difference between S. haematobium and S. mansoni for the same dose, age group, and analyte, and c: significant difference between (R)-PZQ and (S)-PZQ for the same dose, age group, and species. AUC, area under the curve; PSAC, preschool-aged children; PZQ, praziquantel; SAC, school-aged children.