Fig 7. A comprehensive map of PZQ metabolites extracted and combined from studies that focused on the metabolite analysis of PZQ.
I: 8-OH-PZQ [89], II: 4-OH-PZQ [28, 53], III: X-OH-PZQ [84], IV: O-PZQ [28], V:O-PZQ [28], VI: O-PZQ [28], VII: O-PZQ [28], VIII: O-PZQ [28], IX: (-2H)-O-PZQ [28], X: (-2H)-O-PZQ [28], XI/XII: O2-PZQ [28], XIII: O2-PZQ [28], G1: Gluc-PZQ [28], G2/G3: Gluc-O-PZQ [28], G4: (-2H)-Gluc-O-PZQ [28]. The chemical structures and metabolite map were created using ChemDraw Prime v16.0. Gluc, glucuronide; PZQ, praziquantel.