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. Author manuscript; available in PMC: 2020 Nov 20.
Published in final edited form as: Bioconjug Chem. 2019 Nov 1;30(11):2889–2896. doi: 10.1021/acs.bioconjchem.9b00609

Figure 4. Chemical programming of h38C2 IgG1.

Figure 4.

(A) Structures of the β-lactam hapten derivatives of folate (compound 3) and LLP2A (compound 4) and structures of the MS-PODA derivatives of folate (compound 5) and LLP2A (compound 6) used in this study. (B) (Left) Catalytic activity of h38C2 IgG1 (1 μM) before and after conjugation to 5 eq of compounds 2-6 (mean ± SD of triplicates). (Right) Catalytic activity of h38C2 IgG1 (1 μM) before and after conjugation to 1, 2, and 5 eq of compounds 3 and 5 (mean ± SD of triplicates).