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. Author manuscript; available in PMC: 2021 Feb 15.
Published in final edited form as: Cancer Res. 2020 Jun 10;80(16):3305–3318. doi: 10.1158/0008-5472.CAN-20-0057

Fig. 1. Genome-wide shRNA screening identifies PPP2R2A as a CHK1 inhibitor sensitivity gene.

Fig. 1.

(A) Screening workflow. gDNA was isolated from the reference and experimental populations of transduced cells. CHK1i, CHK1 inhibitor (LY2603618). (B) The heatmap depicts the Z scores for two replica screens (C1/C2 for replicas of the control group and E1/E2 for replicas of the treatment group). (C) Plot of average Z scores. Several well-established ATR/CHK1 inhibitor sensitivity or resistance genes are indicated in black. Newly identified hits in our screen are indicated in red.