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. 2020 Sep 25;43(12):1309–1314. doi: 10.1007/s40264-020-01000-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 3 — Top five reported adverse drug reactions (MedDRA^® preferred terms), with number of reported instances, for the included drugs used in treating COVID-19 (left) vs. for the same drugs used in other indications (right), separated by sex. Reports with unknown sex and the MedDRA^® preferred terms off-label use, intentional product use issue, and drug ineffective are excluded. The size of the box represents the proportions within the COVID-19 and VigiBase datasets, respectively. Reports may contain more than one reported preferred term. The legend shows the number of reports for each subset