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Experimental design.
| Group | n | Agent (i.p.) |
|---|---|---|
| CONT | 8 | 1 mL/kg* saline |
| CP | 8 | 10 mg/kg* cisplatin |
| NAC-250 | 8 | 250 mg/kg* N-acetylcysteine |
| CP+NAC | 8 | 10 mg/kg* cisplatin + 4 h later and 2 consecutive days 250 mg/kg* N-acetylcysteine |
*: Rat body weight; n: number of rats in each group; CONT: control group; CP: cisplatin group; NAC-250: N-acetylcysteine group; CP+NAC: cisplatin plus N-acetylcysteine group; i.p.: intraperitoneal.
