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. 2020 Apr 7;15(10):1093–1106. doi: 10.1080/15592294.2020.1747748

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — (a) Enrichment/depletion of CpG island contexts from a Cochran-Mantel-Haenszel test comparing identified CpG loci to all other CpG loci included in the analysis, adjusting for Illumina probe type (a) among the 4,942 CpG loci found to be significantly (p < 0.01) hypomethylated in ipsilateral-normal relative to contralateral-normal tissue, (b) among the 4,620 CpG loci found to be significantly (p < 0.01) hypermethylated in ipsilateral-normal relative to contralateral-normal tissue as well as the subset of 1,421 hypermethylated loci annotated to gene promoter regions, (c) among the 71,407CpG loci found to be significantly (p < 0.01) hypermethylated in tumour relative to contralateral-normal tissue as well as the subset of 30,455 hypermethylated loci annotated to gene promoter regions.