Table 1.
Clinical, biochemical, and bone mineral densitometry parameters of patients with asymptomatic and symptomatic primary hyperparathyroidism before parathyroidectomy.
| Variables | Asymptomatic PHPT, n = 63 | Symptomatic PHPT, n = 28 | P |
|---|---|---|---|
| Women (%) | 82.8 | 77.8 | 0.314 |
| Menopause (%) | 61.5 | 61.9 | 0.815 |
| Smoking habit (%) | 20.6 | 25.9 | 0.715 |
| Age (years) | 51.52 ± 10.47 | 52.40 ± 11.59 | 0.826 |
| BMI (kg/m2) | 29.95 ± 4.72 | 32.13 ± 6.60 | 0.482 |
| Glucose (mg/dL) | 90.85 ± 9.99 | 89.60 ± 9.01 | 0.934 |
| Albumin (mg/dL) | 4.53 ± 0.22 | 4.41 ± 0.15 | 0.352 |
| Creatinine (mg/dL) | 0.75 ± 0.15 | 0.68 ± 0.16 | 0.408 |
| Calcium (mg/dL) | 10.41 ± 0.64 | 11.34 ± 0.76 | <0.001 |
| Phosphorus (mg/dL) | 2.61 ± 0.37 | 2.50 ± 0.44 | 0.030 |
| iPTH (pg/dL) | 194.76 ± 136.63 | 347.53 ± 202.24 | <0.001 |
| ALP (mg/dL) | 101.52 ± 40.08 | 158.20 ± 74.90 | <0.001 |
| 25(OH)D (ng/mL) | 20.15 ± 24.11 | 9.82 ± 9.13 | 0.003 |
| Magnesium (mg/dL) | 2.13 ± 0.19 | 2.12 ± 0.23 | 0.935 |
| TSH (mg/dL) | 2.09 ± 1.29 | 1.56 ± 0.81 | 0.728 |
| Lumbar spine BMD (g/cm2) | 0.83 ± 0.15 | 0.72 ± 0.12 | 0.137 |
| Total hip BMD (g/cm2) | 0.78 ± 0.13 | 0.71 ± 0.15 | 0.951 |
| Femoral neck BMD (g/cm2) | 0.67 ± 0.11 | 0.63 ± 0.09 | 0.879 |
| Lumbar spine T-score | –1.99 ± 1.41 | –2.92 ± 1.17 | 0.020 |
| Total hip T-score | –1.44 ± 1.14 | –1.98 ± 1.30 | 0.242 |
| Femoral neck T-score | –1.83 ± 1.17 | –2.32 ± 1.09 | 0.165 |
| Osteoporosis at lumbar spine (%) | 37.5 | 63.0 | 0.026 |
| Osteoporosis at total hip (%) | 12.5 | 29.6 | 0.050 |
| Osteoporosis at femoral neck (%) | 20.6 | 40.7 | 0.048 |
| Osteoporosis at least one site (%) | 39.1 | 66.7 | 0.016 |
| Nephrolithiasis (%) | 4.6 | 18.2 | 0.032 |
| Urinary calcium excretion (mg/24 h) | 362.61 ± 175.20 | 437.33 ± 87.18 | 0.016 |
| Adenoma volume (cm3) | 0.47 ± 0.56 | 2.95 ± 3.49 | 0.027 |
Continuous variables are presented as mean ± standard deviation (SD). Categorical variables are presented as percentage (%).
BMI, Body mass index; TSH, thyroid-stimulating hormone; ALP, alkaline phosphatase; iPTH, intact parathyroid hormone, BMD, bone mineral density; 25(OH)D, 25-hydroxy-vitamin D.