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. 2020 Mar 5;15(8):887–899. doi: 10.1080/15592294.2020.1737355

Figure 1.

Figure 1.

Hydromxymethylation-associated genes detected in sIUGR twin pairs through hMeDIP-chip and mRNA sequencing. (a) Schematic representation for identifying hydroxymethylation-associated genes. The putative targets obtained by overlapping the differentially expressed mRNAs and differentially hydroxymethylation peaks in promoter region. (b) The differentially expressed mRNAs and differentially hydroxymethylation peaks between two placental shares in sIUGR group and normal MCDA group shown on the heatmap. (c) The differentially expressed mRNAs between larger and smaller placental shares of sIUGR plotted in the volcano plot. One hundred eighty-one upregulated genes and 614 downregulated genes identified in smaller placental shares of the sIUGR group. (d) Expression of hydroxymethylation-regulated associated genes detected in the smaller placental shares compared to the larger ones in sIUGR twin pairs by quantitative RT-PCR.