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. 2020 Aug 31;35(10):2336–2347. doi: 10.1093/humrep/deaa192

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© The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — PCOS was associated with increased risks of neuropsychiatric disorders in offspring irrespective of, but higher with perinatal problems. PCOS refers to ICD-9: 256.4 and 628.0; ICD-10: E28.2 and N97.0. Perinatal problems were defined as birth before gestational week 37 or a birth weight <2500 g, or small for gestational age. Births to mothers with no PCOS and no perinatal problems were used as the reference. The analyses were adjusted for maternal age, mother’s country of birth (Finland or not), mother married at birth (yes/no), maternal smoking (yes/no), parity (0 or ≥1), maternal psychiatric disorder (yes/no), maternal purchase of N05 and N06 during pregnancy (yes/no) and maternal systemic inflammatory disease (yes/no). All children were followed up until 2018. Reference group was births to mothers with no PCOS and no perinatal problems (n = 935 908).