Table II.
Demographic characteristic of birth cohort between 1996 and 2014 in Finland stratified by maternal PCOS.
| Maternal PCOS (n = 24 682) | No maternal PCOS (n = 1 073 071) | |
|---|---|---|
| Maternal age at delivery (years) | ||
| <25 | 3335 (13.5) | 199 630 (18.6) |
| 25–29 | 7622 (30.9) | 340 611 (31.7) |
| 30–34 | 8541 (34.6) | 334 348 (31.2) |
| ≥35 | 5184 (21.0) | 198 484 (18.5) |
| Pre-pregnancy BMI (kg/m2) | ||
| <18.5 | 419 (1.7) | 22 471 (2.1) |
| 18.5–24 | 8656 (35.1) | 373 050 (34.8) |
| 25–29 | 3897 (15.8) | 129 421 (12.1) |
| 30–34 | 2216 (9.0) | 47 180 (4.4) |
| ≥35 | 1301 (5.3) | 22 210 (2.1) |
| Missing | 8193 (33.2) | 478 739 (44.6) |
| Parity ≥1 | 12 147 (49.2) | 441 121 (41.1) |
| Mother born in Finland | 22 670 (91.8) | 987 139 (92.0) |
| Mother married at delivery | 16 554 (67.1) | 636 044 (59.3) |
| Non-smoking during pregnancy | 20 865 (84.5) | 885 129 (82.5) |
| Maternal systemic inflammatory disorders | 384 (1.6) | 11 124 (1.0) |
| Maternal psychiatric disorders | 619 (2.5) | 19 867 (1.9) |
| Maternal prescription of psychotropic N05/N06 during pregnancy | 1596 (6.5) | 47 650 (4.4) |
| Cesarean delivery | 5698 (23.1) | 154 953 (14.4) |
| Fertility treatment | 3466 (14.0) | 22 706 (2.1) |
| Preeclampsia | 1037 (4.2) | 28 962 (2.7) |
| GDM | 3764 (15.2) | 89 384 (8.3) |
| Perinatal problems | 4287 (17.4) | 137 163 (12.8) |
| Female offspring | 11 949 (48.4) | 524 38 (48.9) |
Values are expressed as n (%). PCOS refers to polycystic ovary syndrome defined by ICD-9: 256.4 and 628.0; ICD-10: E28.2 and N97.0. Perinatal problem is defined as birth before gestational week 37, or birth weight <2500 g, or small for gestational age according to Finnish sex-specific standards (Sankilampi et al., 2013), based on the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society (Clayton et al., 2007). GDM defined by ICD-10 O24.4. Preeclampsia was identified by ICD-10 O14. Fertility treatment refers to in vitro fertilization/intracytoplasmic sperm injection (check-box in the MBR).
GDM, gestational diabetes mellitus.